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Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity
- Singh, Hardev;
- Kim, Seo Jin;
- Kang, Dong Hoon;
- Kim, Hye-Ri;
- Sharma, Amit;
- ... Kim, Jong Seung;
- 외 2명
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Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.
키워드
HEPATOCELLULAR-CARCINOMA; IN-VIVO; CANCER-THERAPY; LIVER-CANCER; CHEMOTHERAPY; PRODRUG; AGENTS; THERANOSTICS; DOXORUBICIN; ACTIVATION
- 제목
- Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity
- 저자
- Singh, Hardev; Kim, Seo Jin; Kang, Dong Hoon; Kim, Hye-Ri; Sharma, Amit; Kim, Won Young; Kang, Chulhun; Kim, Jong Seung
- 발행일
- 2018-11-11
- 유형
- Article
- 권
- 54
- 호
- 87
- 페이지
- 12353 ~ 12356