Melanogenesis inhibitory pregnane glycosides from Cynanchum atratum

초록

Bioassay-guided fractionation of the methanolic extract from the roots of Cynanchum atratum has resulted in the isolation of three new pregnane glycosides (1-3) along with four known compounds (4-7). Their structures were identified by analysis of the spectroscopic data including extensive 2D NMR. All of the isolates were evaluated for their potential to inhibit the melanin production in a-melanocyte stimulating hormone (alpha-MSH)-activated B16 melanoma cells. Of these, compounds 4-7 dosedependently inhibited the melanin production with the IC50 values ranging from 4 mu M to 33 mu M. (C) 2018 Elsevier Ltd. All rights reserved.

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