Biology of cognitive aging across species

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초록

Aging is associated with cognitive decline, which can critically affect quality of life. Examining the biology of cognitive aging across species will lead to a better understanding of the fundamental mechanisms involved in this process, and identify potential interventions that could help to improve cognitive function in aging individuals. This minireview aimed to explore the mechanisms and processes involved in cognitive aging across a range of species, from flies to rodents, and covers topics, such as the role of reactive oxygen species and autophagy/mitophagy in cognitive aging. Overall, this literature provides a comprehensive overview of the biology of cognitive aging across species, highlighting the latest research findings and identifying potential avenues for future research.

키워드

cerebellum; cognitive aging; Drosophila; mouse; mushroom body; LONG-TERM POTENTIATION; OLFACTORY MEMORY FORMATION; PREFRONTAL CORTEX; HYDROGEN-PEROXIDE; CONSOLIDATED MEMORY; SYNAPTIC PLASTICITY; RYANODINE RECEPTOR; EYEBLINK RESPONSE; NEURONS FORM; DPM NEURONS
제목
Biology of cognitive aging across species
저자
Kakizawa, Sho; Park, Joong-Jean; Tonoki, Ayako
DOI
10.1111/ggi.14782
발행일
2023-12-21
유형
Review; Early Access
저널명
Geriatrics and Gerontology International
권
24
호
S1
페이지
15 ~ 24