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SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy
- Park, Yoon Kyung;
- Jangili, Paramesh;
- Zi, Soyu;
- Kang, Rae Hyung;
- Kim, Dokyoung;
- ... Kim, Jong Seung
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4초록
A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.
- 제목
- SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy
- 저자
- Park, Yoon Kyung; Jangili, Paramesh; Zi, Soyu; Kang, Rae Hyung; Kim, Dokyoung; Kim, Jong Seung
- 발행일
- 2022-09-29
- 유형
- Article
- 권
- 58
- 호
- 78
- 페이지
- 10941 ~ 10944