Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy

Park, Yong Il; Kim, Hyung Min; Kim, Jeong Hyun; Moon, Kyung Chul; Yoo, Byeongjun; Lee, Kang Taek; Lee, Nohyun; Choi, Yoonseok; Park, Wooram; Ling, Daishun; Na, Kun; Moon, Woo Kyung; Choi, Seung Hong; Park, Hong Seok; Yoon, Soo-Young; Suh, Yung Doug; Lee, Sung Ho; Hyeon, Taeghwan

doi:10.1002/adma.201202433

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Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy

Park, Yong Il;
Kim, Hyung Min;
Kim, Jeong Hyun;
Moon, Kyung Chul;
Yoo, Byeongjun;
... Park, Hong Seok;
... Yoon, Soo-Young;
... Lee, Sung Ho;
외 10명

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396

초록

Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

키워드

luminescence; magnetic resonance imaging; nanoparticles; photodynamic therapy; upconversion; UP-CONVERSION NANOPARTICLES; IRON-OXIDE NANOPARTICLES; QUANTUM DOTS; CONTRAST AGENTS; UPCONVERTING NANOPARTICLES; FLUORESCENT NANOCRYSTALS; NAYF4 NANOCRYSTALS; CANCER; NANOPROBES; NANOPHOSPHORS

제목: Theranostic Probe Based on Lanthanide-Doped Nanoparticles for Simultaneous In Vivo Dual-Modal Imaging and Photodynamic Therapy

저자: Park, Yong Il; Kim, Hyung Min; Kim, Jeong Hyun; Moon, Kyung Chul; Yoo, Byeongjun; Lee, Kang Taek; Lee, Nohyun; Choi, Yoonseok; Park, Wooram; Ling, Daishun; Na, Kun; Moon, Woo Kyung; Choi, Seung Hong; Park, Hong Seok; Yoon, Soo-Young; Suh, Yung Doug; Lee, Sung Ho; Hyeon, Taeghwan

DOI: 10.1002/adma.201202433

발행일: 2012-11-08

유형: Article

저널명: Advanced Materials

권: 24

호: 42

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