Pep-1 Peptide-Modified Liposomal Carriers for Intracellular Delivery of Gold Nanoparticles

Kang, Myung Joo; Lee, Sangyeop; Km, Bo Kyun; Eum, Jae Yoon; Park, Sang Han; Kang, Mm Hyung; Oh, Chil Hwan; Choo, Jaebum; Choi, Young Wook

doi:10.1248/cpb.59.109

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Pep-1 Peptide-Modified Liposomal Carriers for Intracellular Delivery of Gold Nanoparticles

Kang, Myung Joo;
Lee, Sangyeop;
Km, Bo Kyun;
Eum, Jae Yoon;
Park, Sang Han;
외 4명

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3

초록

A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to Increase the intracellular delivery of gold nanoparticles (Au NPs) Au NPs with a mean diameter of 13 nm were successfully encapsulated Into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm The Au NP-loaded liposomal carrier was physically characterized as 150-170 nm in size and 45 mV in zeta potential Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes Into the cells was Increased by Pep1-Lipo carriers compared to bare Au NPs In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs

키워드

gold nanoparticle; liposome; Pep 1 peptide; nanocarrier; intracellular delivery; ENHANCED RAMAN-SPECTROSCOPY; MAMMALIAN-CELLS; CELLULAR UPTAKE; LIVING CELLS; NANOCRYSTALS; INTERNALIZATION; INJECTION; TRACKING; RELEASE; SENSORS

제목: Pep-1 Peptide-Modified Liposomal Carriers for Intracellular Delivery of Gold Nanoparticles

저자: Kang, Myung Joo; Lee, Sangyeop; Km, Bo Kyun; Eum, Jae Yoon; Park, Sang Han; Kang, Mm Hyung; Oh, Chil Hwan; Choo, Jaebum; Choi, Young Wook

DOI: 10.1248/cpb.59.109

발행일: 2011-01

유형: Article

저널명: Chemical and Pharmaceutical Bulletin

권: 59

호: 1

페이지: 109 ~ 112