Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Yuk, Soon Hong; Oh, Keun Sang; Koo, Heebeom; Jeon, Hyesung; Kim, Kwangmeyung; Kwon, Ick Chan

doi:10.1016/j.biomaterials.2011.07.017

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Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

Yuk, Soon Hong;
Oh, Keun Sang;
Koo, Heebeom;
Jeon, Hyesung;
Kim, Kwangmeyung;
외 1명

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39

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41

초록

The Pluronic nanoparticles (NPs) composed of Pluronic (F-68) and liquid polyethylene glycol (PEG, molecular wt: 400) containing docetaxel (DTX) were stabilized with the vesicle fusion. When DTX-loaded Pluronic NPs were mixed with vesicles in the aqueous medium, DTX-loaded Pluronic NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using FE-SEM, cryo-TEM and a particle size analyzer. To apply multi-core vesicle NPs as a delivery system for DTX, a model anti-cancer drug, the release pattern of DTX was observed and the tumor growth was monitored by injecting the DTX-loaded multi-core vesicle NPs into the tail veins of tumor-bearing mice. We also evaluated the time-dependent excretion profile, in vivo biodistribution, circulation time, and tumor targeting capability of multi-core vesicle NPs using a non-invasive live animal imaging technology. (C) 2011 Elsevier Ltd. All rights reserved.

키워드

Drug delivery; Multi-core vesicle nanoparticles; Pluronic; Docetaxel; Chemotherapy; POLYETHYLENE-GLYCOL; LIPOSOME FUSION; LUNG-CANCER; DOCETAXEL; PACLITAXEL; BILAYER; INCREASES; RELEASE

제목: Multi-core vesicle nanoparticles based on vesicle fusion for delivery of chemotherapic drugs

저자: Yuk, Soon Hong; Oh, Keun Sang; Koo, Heebeom; Jeon, Hyesung; Kim, Kwangmeyung; Kwon, Ick Chan

DOI: 10.1016/j.biomaterials.2011.07.017

발행일: 2011-11

유형: Article

저널명: Biomaterials

권: 32

호: 31

페이지: 7924 ~ 7931