Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of alpha-MSH-stimulated melanogenesis

Jo, Hyeju; Choi, Minho; Sim, Jaeuk; Viji, Mayavan; Li, Siyuan; Lee, Young Hee; Kim, Youngsoo; Seo, Seung-Yong; Zhou, Yuanyuan; Lee, Kiho; Kim, Wun-Jae; Hong, Jin Tae; Lee, Heesoon; Jung, Jae-Kyung

doi:10.1016/j.bmcl.2017.06.011

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Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of alpha-MSH-stimulated melanogenesis

Jo, Hyeju;
Choi, Minho;
Sim, Jaeuk;
Viji, Mayavan;
Li, Siyuan;
... Lee, Kiho;
외 8명

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23

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26

초록

We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of alpha-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities. (C) 2017 Elsevier Ltd. All rights reserved.

키워드

Caffeic acid; Melanogenesis; alpha-MSH; Caffeamide; Skin whitening; B16 MELANOMA-CELLS; TYROSINASE INHIBITORS; DOWN-REGULATION; SIGNALING PATHWAYS; SKIN PIGMENTATION; AGENTS; MELANOCYTES; DISCOVERY; ESTER

제목: Synthesis and biological evaluation of caffeic acid derivatives as potent inhibitors of alpha-MSH-stimulated melanogenesis

저자: Jo, Hyeju; Choi, Minho; Sim, Jaeuk; Viji, Mayavan; Li, Siyuan; Lee, Young Hee; Kim, Youngsoo; Seo, Seung-Yong; Zhou, Yuanyuan; Lee, Kiho; Kim, Wun-Jae; Hong, Jin Tae; Lee, Heesoon; Jung, Jae-Kyung

DOI: 10.1016/j.bmcl.2017.06.011

발행일: 2017-08-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 27

호: 15

페이지: 3374 ~ 3377