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Inhibition of Diacylglycerol Acyltransferase by Phenylpyropenes Produced by Penicillium griseofulvum F1959
- Lee, Seung Woong;
- Rho, Mun-Chual;
- Choi, Jung-Ho;
- Kim, Koanhoi;
- Choi, Yong Seok;
- 외 2명
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Phenylpyropenes A, B, and C, isolated from Penicillium griseofulvum F1959, inhibited DGAT in rat liver microsomes with IC50 values of 78.7 +/- 1.6, 21.7 +/- 0.2, and 11.04 +/- 0.2 mu M, respectively. In addition, a kinetic analysis using a Lineweaver-Burk plot revealed that phenylpyropene C was a noncompetitive inhibitor of DGAT. The apparent Michaelis constant (K-m) value and inhibition constant (K-i) value were calculated to be 8 mu M and 10.4 mu M, respectively. Moreover, phenylpyropene C inhibited triglyceride formation in HepG2 cells.
키워드
Penicillium griseofulvum F1959; diacylglycerol acyltransferase (DGAT); phenylpyropene; triglyceride; hepG2 cell; ACYL-COA; DGAT
- 제목
- Inhibition of Diacylglycerol Acyltransferase by Phenylpyropenes Produced by Penicillium griseofulvum F1959
- 저자
- Lee, Seung Woong; Rho, Mun-Chual; Choi, Jung-Ho; Kim, Koanhoi; Choi, Yong Seok; Lee, Hyun Sun; Kim, Young Kook
- 발행일
- 2008-11
- 유형
- Article
- 권
- 18
- 호
- 11
- 페이지
- 1785 ~ 1788