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Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF(1) production
- Lee, Bit;
- Kwak, Jae-Hwan;
- Huang, Shin-Won;
- Jang, Jae-Yong;
- Lim, Sanglae;
- ... Lee, Kiho;
- 외 8명
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WEB OF SCIENCE
21Citations
SCOPUS
23초록
A series of novel 4-O-methylhonokiol analogs were synthesized in light of revealing structure-activity relationship for inhibitory effect of COX-2 enzyme. The key strategy of the molecular design was oriented towards modification of the potential metabolic soft spots (e. g., phenol and olefin) or by altering the polar surface area via incorporating heterocycles such as isoxazole and triazole. Most of all exhibited the inhibitory effects on COX-2 and PGF(1) production but not macrophage NO production. Especially, aryl carbamates 10 and 11 exhibited more potent inhibitory activity against COX-2 and PGF(1) production. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
키워드
4-O-Methylhonokiol; Cyclooxygenase-2 (COX-2); Aryl carbamate; Isoxazole; Triazole; ONE-POT SYNTHESIS; MAGNOLIA-OFFICINALIS; MEMORY IMPAIRMENT; ETHANOL EXTRACT; 1,2,3-TRIAZOLES; CONSTITUENTS; OBOVATOL; DISEASE
- 제목
- Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF(1) production
- 저자
- Lee, Bit; Kwak, Jae-Hwan; Huang, Shin-Won; Jang, Jae-Yong; Lim, Sanglae; Kwak, Young-Shin; Lee, Kiho; Kim, Hyung Sook; Han, Sang-Bae; Hong, Jin-Tae; Lee, Heesoon; Song, Sukgil; Seo, Seung-Yong; Jung, Jae-Kyung
- 발행일
- 2012-05-01
- 유형
- Article
- 권
- 20
- 호
- 9
- 페이지
- 2860 ~ 2868