Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

Hong, Seong Su; Lee, Seon A.; Kim, Nahyun; Hwang, Ji Sang; Han, Xiang Hua; Lee, Mi Kyeong; Jung, Jae Kyung; Hong, Jin Tae; Kim, Youngsoo; Lee, Dongho; Hwang, Bang Yeon

doi:10.1016/j.bmcl.2010.11.095

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Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

Hong, Seong Su;
Lee, Seon A.;
Kim, Nahyun;
Hwang, Ji Sang;
Han, Xiang Hua;
... Lee, Dongho;
외 5명

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5

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5

초록

A new pyrrolidinone diterpenoid, excisusin F(1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC50 value of 10.4 and 3.8 mu M, respectively. (C) 2011 Published by Elsevier Ltd.

키워드

Isodon excisus; Lamiaceae; Pyrrolidinone diterpenoid; Nitric oxide inhibitor; ENT-KAURENE DITERPENOIDS; KAPPA-B ACTIVATION; KAURANE DITERPENOIDS; NO PRODUCTION; CONSTITUENTS; LEAVES; MEGASTIGMANE; RUBESCENS; JAPONICUS

제목: Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

저자: Hong, Seong Su; Lee, Seon A.; Kim, Nahyun; Hwang, Ji Sang; Han, Xiang Hua; Lee, Mi Kyeong; Jung, Jae Kyung; Hong, Jin Tae; Kim, Youngsoo; Lee, Dongho; Hwang, Bang Yeon

DOI: 10.1016/j.bmcl.2010.11.095

발행일: 2011-02-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 21

호: 4

페이지: 1279 ~ 1281