Balancing antimicrobial performance with hemocompatibility in amphiphilic homopolymers

Zhu, Zhiyuan; Jeong, Gookyeong; Kim, Seung-Jin; Gadwal, Ikhlas; Choe, Youngson; Bang, Joona; Oh, Min-Kyu; Khan, Anzar; Rao, Jingyi

doi:10.1002/pola.29213

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Balancing antimicrobial performance with hemocompatibility in amphiphilic homopolymers

Zhu, Zhiyuan;
Jeong, Gookyeong;
Kim, Seung-Jin;
Gadwal, Ikhlas;
Choe, Youngson;
... Oh, Min-Kyu;
외 3명

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초록

This work establishes amphiphilic polymethacrylates as new antimicrobial candidates that can be synthesized through a combination of controlled free radical polymerization and sequential postpolymerization modification protocols. When conjugated with a polyethylene glycol segment, the block copolymers exhibit a balanced performance between high antibacterial activity and high hemocompatibility.

키워드

amphiphilic polymers; antibacterial polymers; poly(glycidyl methacrylate); sequential post-polymerization modification; thiol-epoxy reaction; DE-NOVO DESIGN; POST-POLYMERIZATION MODIFICATION; THIOL-EPOXY; POSTPOLYMERIZATION MODIFICATION; HEMOLYTIC ACTIVITIES; SYNTHETIC MIMICS; POLYMERS; ANTIBACTERIAL; COPOLYMERS; DERIVATIVES

제목: Balancing antimicrobial performance with hemocompatibility in amphiphilic homopolymers

저자: Zhu, Zhiyuan; Jeong, Gookyeong; Kim, Seung-Jin; Gadwal, Ikhlas; Choe, Youngson; Bang, Joona; Oh, Min-Kyu; Khan, Anzar; Rao, Jingyi

DOI: 10.1002/pola.29213

발행일: 2018-11-01

유형: Article

저널명: Journal of Polymer Science, Part A: Polymer Chemistry

권: 56

호: 21

페이지: 2391 ~ 2396