Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

Shuo, Yuan; Zhang, Chenyue; Yang, Xueyuan; Liu, Feng; Zhang, Qi; Li, Annan; Ma, Jun; Lee, Dongho; Ohizumi, Yasushi; Guo, Yuanqiang

doi:10.1007/s11418-019-01324-5

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Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

Shuo, Yuan;
Zhang, Chenyue;
Yang, Xueyuan;
Liu, Feng;
Zhang, Qi;
... Lee, Dongho;
외 4명

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WEB OF SCIENCE

10

Citations

SCOPUS

11

초록

A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1-4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 mu M against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. [GRAPHICS] .

키워드

Casearia kurzii; Clerodane diterpenoids; Cytotoxic activities; Apoptosis; Cell cycle; LEAVES; TWIGS; ROOTS; APOPTOSIS; PRODUCTS; BARK

제목: Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

저자: Shuo, Yuan; Zhang, Chenyue; Yang, Xueyuan; Liu, Feng; Zhang, Qi; Li, Annan; Ma, Jun; Lee, Dongho; Ohizumi, Yasushi; Guo, Yuanqiang

DOI: 10.1007/s11418-019-01324-5

발행일: 2019-09

유형: Article

저널명: Journal of Natural Medicines

권: 73

호: 4

페이지: 826 ~ 833