Production and characterization of calcium phosphate (CaP) whisker-reinforced poly(epsilon-caprolactone) composites as bone regenerative

초록

Calcium phosphate (Cap) whisker-reinforced poly(epsilon-caprolactone) (PCL) composites with various CaP contents (0, 5, 10, and 20 wt.%) were prepared by dispersing CaP whiskers in a PCL solution. To accomplish this. CaP whiskers were synthesized by treating tricalcium phosphate (TCP) powders in a hydrogen peroxide (H2O2) solution at 90 degrees C for 48 h. All the prepared composites showed well dispersed CaP whiskers in the PCL matrix without severe agglomeration. As the CaP content was increased from 0 to 20 wt.%, the ultimate tensile strength decreased from 13.2 +/- 0.9 to 8.8 +/- 0.4 MPa, while the elastic modulus increased significantly from 173 +/- 21 to 334 +/- 24 MPa. In addition, the addition of CaP whiskers to the PCL matrix improved the biocompatibility of the composites remarkably. (C) 2010 Elsevier B.V. All rights reserved.

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