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Nitric oxide inhibitory and cytotoxic secondary metabolites from Talaromyces sp. BHM8-7
- Han, Jae Sang;
- Lee, Dahyeon;
- Kim, Jun Gu;
- Jang, Joon Su;
- Dang, Vu Quan;
- ... Lee, Dongho;
- 외 4명
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1초록
Two previously undescribed sesquiterpenes (1 and 2), one meroterpenoid (3), and one cyclic peptide (4), together with four known metabolites (5-8) were isolated from Talaromyces sp. BHM8-7. Their structures were elucidated by comprehensive spectroscopic techniques, such as 1D and 2D NMR, HRESIMS, ECD calculations, and the advanced Marfey's method following acid hydrolysis. Among the isolates, compound 5 exhibited significant inhibitory activity against nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells without observable cytotoxicity. In addition, compounds 1 and 5 displayed potent cytotoxic effects on both SK-OV-3 and HCT-8 cells.
키워드
Sesquiterpenes; Meroterpene; Cyclic peptide; Anti-inflammatory effect; Cytotoxicity; Talaromyces sp; MARINE ISOLATE; FUNGUS; MEROTERPENOIDS; SESQUITERPENE; VERMISTATIN
- 제목
- Nitric oxide inhibitory and cytotoxic secondary metabolites from Talaromyces sp. BHM8-7
- 저자
- Han, Jae Sang; Lee, Dahyeon; Kim, Jun Gu; Jang, Joon Su; Dang, Vu Quan; Kim, Woo Jin; Lee, Dongho; Lee, Mi Kyeong; Lee, Jin Woo; Hwang, Bang Yeon
- 발행일
- 2026-07
- 유형
- Article
- 저널명
- Phytochemistry
- 권
- 247