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Molecular networking-guided isolation of melanogenesis inhibitory dihydro-<i>β</i>-agarofuran sesquiterpenoids from<i> Celastrus</i><i> orbiculatus</i>
- Kim, Jun Gu;
- Han, Jae Sang;
- Cho, Yong Beom;
- An, Beom Kyun;
- Lee, Dongho;
- 외 2명
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WEB OF SCIENCE
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SCOPUS
3초록
Seven previously undescribed dihydro-/3-agarofurans (1-7) together with 28 known compounds were isolated from Celastrus orbiculatus fruits using LC-MS/MS-based molecular networking-guided purification. Their structures were elucidated through 1D and 2D-NMR, HRESIMS analysis, and ECD quantum chemical calculations. The inhibitory effects of all isolated compounds on a-MSH-induced melanin production in B16F0 melanoma cells were tested. Compounds 1, 11, 12, 19-21, 23, 29, 31, 34, and 35 showed significant inhibitory effects on melanin production with IC50 values ranging from 11.3 to 30.1 mu M.
키워드
Celastrus orbiculatus; Celastraceae; Dihydro-/3-agarofuran; Molecular networking; GNPS; Melanin production; POLYOL ESTERS; FRUITS; AGENTS; SEEDS
- 제목
- Molecular networking-guided isolation of melanogenesis inhibitory dihydro-<i>β</i>-agarofuran sesquiterpenoids from<i> Celastrus</i><i> orbiculatus</i>
- 저자
- Kim, Jun Gu; Han, Jae Sang; Cho, Yong Beom; An, Beom Kyun; Lee, Dongho; Lee, Mi Kyeong; Hwang, Bang Yeon
- 발행일
- 2025-01
- 유형
- Article
- 저널명
- Phytochemistry
- 권
- 229