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Doxorubicin-loaded multilayer nanoparticles with enhanced antitumor efficacy and reduced cardiotoxicity
- Kil, Ye Chan;
- Kim, Yeaji;
- Choi, Aryeong;
- Kim, Jae Yeon;
- Park, Seong Jin;
- ... Jung, Yong Woo;
- 외 2명
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1초록
The multilayer nanoparticles (Multilayer NPs) were designed and characterized for the application to chemotherapy with enhanced therapeutic efficacy and reduced side effects. Multilayer NPs are composed of a doxorubicin (DOX)-loaded core and a multi-shell comprising Solutol, lecithin, and Pluronic. Multilayer NP structure was verified using a transmission electron microscope (TEM) and particle size analyzer. Biodistribution, antitumor efficacy, and tissue penetration efficiency were examined with tumor-bearing mice to understand the antitumor efficacy of Multilayer nanostructure. Finally, cardiotoxicity was evaluated to explain the reduced side effects of DOX.
키워드
Doxorubicin; Solutol; Pluronic F127; Enhanced uptake; Cardiotoxicity; The multilayer nanoparticles; POLYMERIC MICELLES; BLOCK-COPOLYMERS; DEEP PENETRATION; DRUG-DELIVERY; NANOCARRIERS; INHIBITION; SIZE
- 제목
- Doxorubicin-loaded multilayer nanoparticles with enhanced antitumor efficacy and reduced cardiotoxicity
- 저자
- Kil, Ye Chan; Kim, Yeaji; Choi, Aryeong; Kim, Jae Yeon; Park, Seong Jin; Byun, Youngro; Jung, Yong Woo; Yuk, Soon Hong
- 발행일
- 2026-02
- 유형
- Article
- 권
- 34
- 호
- 2
- 페이지
- 243 ~ 253
- 언어
- ENG
- 출판사
- POLYMER SOC KOREA
- 발행국가
- 대한민국
- 분량
- 11 페이지
- ISSN
- E 2092-7673
P 1598-5032