Doxorubicin-loaded multilayer nanoparticles with enhanced antitumor efficacy and reduced cardiotoxicity

Kil, Ye Chan; Kim, Yeaji; Choi, Aryeong; Kim, Jae Yeon; Park, Seong Jin; Byun, Youngro; Jung, Yong Woo; Yuk, Soon Hong

doi:10.1007/s13233-025-00468-6

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Doxorubicin-loaded multilayer nanoparticles with enhanced antitumor efficacy and reduced cardiotoxicity

Kil, Ye Chan;
Kim, Yeaji;
Choi, Aryeong;
Kim, Jae Yeon;
Park, Seong Jin;
... Jung, Yong Woo;
외 2명

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초록

The multilayer nanoparticles (Multilayer NPs) were designed and characterized for the application to chemotherapy with enhanced therapeutic efficacy and reduced side effects. Multilayer NPs are composed of a doxorubicin (DOX)-loaded core and a multi-shell comprising Solutol, lecithin, and Pluronic. Multilayer NP structure was verified using a transmission electron microscope (TEM) and particle size analyzer. Biodistribution, antitumor efficacy, and tissue penetration efficiency were examined with tumor-bearing mice to understand the antitumor efficacy of Multilayer nanostructure. Finally, cardiotoxicity was evaluated to explain the reduced side effects of DOX.

키워드

Doxorubicin; Solutol; Pluronic F127; Enhanced uptake; Cardiotoxicity; The multilayer nanoparticles; POLYMERIC MICELLES; BLOCK-COPOLYMERS; DEEP PENETRATION; DRUG-DELIVERY; NANOCARRIERS; INHIBITION; SIZE

제목: Doxorubicin-loaded multilayer nanoparticles with enhanced antitumor efficacy and reduced cardiotoxicity

저자: Kil, Ye Chan; Kim, Yeaji; Choi, Aryeong; Kim, Jae Yeon; Park, Seong Jin; Byun, Youngro; Jung, Yong Woo; Yuk, Soon Hong

DOI: 10.1007/s13233-025-00468-6

발행일: 2026-02

유형: Article

저널명: Macromolecular Research

권: 34

호: 2

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