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Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells
- Jin, Qinghao;
- Lee, Jin Woo;
- Jang, Hari;
- Choi, Ji Eun;
- Lee, Dongho;
- 외 4명
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24초록
Eight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 mu M.
키워드
NF-KAPPA-B; POTENTIAL ANTIINFLAMMATORY AGENTS; INDUCED NO PRODUCTION; RAW264.7 CELLS; INOS EXPRESSION; GENUS INULA; LACTONES; BRITANNICA; EUDESMANOLIDES; GUAIANOLIDES
- 제목
- Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells
- 저자
- Jin, Qinghao; Lee, Jin Woo; Jang, Hari; Choi, Ji Eun; Lee, Dongho; Hong, Jin Tae; Kim, Youngsoo; Lee, Mi Kyeong; Hwang, Bang Yeon
- 발행일
- 2016-06
- 유형
- Article
- 권
- 79
- 호
- 6
- 페이지
- 1548 ~ 1553
- 언어
- ENG
- 출판사
- AMER CHEMICAL SOC
- 발행국가
- 미국
- 분량
- 6 페이지
- ISSN
- E 1520-6025
P 0163-3864