Metal-Free Transamidation of Primary Amides using Trimethylsilyl Chloride

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23
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SCOPUS

25

초록

A metal-free transamidation of primary amides was developed. Trimethylsilyl chloride (TMSCl) acted as the activator in transamidation. In the presence of TMSCl, primary amides reacted with primary amines to yield transamidated secondary amides in NMP solvent. The transamidation of benzamide with secondary amines for the formation of tertiary amides succeeds in an NMP/CHCl3 solvent mixture.

키워드

transamidationmetal-free chemistryamidesaminestrimethylsilyl chlorideCATALYZED TRANSAMIDATIONEFFICIENT CATALYSTCARBOXYLIC-ACIDSSECONDARY AMIDESCARBOXAMIDESAMINESSOLVENTUREASCOMPLEX
제목
Metal-Free Transamidation of Primary Amides using Trimethylsilyl Chloride
저자
Yu, SubeenSong, Kwang HoLee, Sunwoo
DOI
10.1002/ajoc.201900216
발행일
2019-09
유형
Article
저널명
Asian Journal of Organic Chemistry
8
9
페이지
1613 ~ 1616