Electrosynthesis unleashed: green pathways to natural product synthesis

초록

Electrosynthesis is reshaping natural product total synthesis by replacing stoichiometric oxidants and reductants, reducing waste, and enabling orthogonal reactivity. We highlight recent advances that demonstrate mediator and catalyst platforms alongside sustainability metrics, including anodic functionalization, reductive couplings, and electrochemical oxidative dearomatization-induced (ODI)-[5+2] cascades. These strategies deliver safer, scalable, and low-carbon synthetic routes, extending access to targets previously unattainable by conventional methods.

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