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Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family
- Han, Byeong-Gu;
- Jeong, Kyung-Chae;
- Cho, Jea-Won;
- Jeong, Byung-Cheon;
- Song, Hyun Kyu;
- 외 4명
WEB OF SCIENCE
0SCOPUS
0초록
Pyrococcus furiosus PF2050 is an uncharacterized putative protein that contains two DUF2666 domains. Functional and structural studies of PF2050 have not previously been performed. In this study, we determined the crystal structure of PF2050. The structure of PF2050 showed that the two DUF2666 domains interact tightly, forming a globular structure. Each DUF2666 domain comprises an antiparallel beta-sheet and an alpha-helical bundle. One side of the PF2050 structure has a positively charged basic cleft, which may have a DNA-binding function. Furthermore, we confirmed that PF2050 interacts with circular and linear dsDNA. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
키워드
- 제목
- Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family
- 저자
- Han, Byeong-Gu; Jeong, Kyung-Chae; Cho, Jea-Won; Jeong, Byung-Cheon; Song, Hyun Kyu; Lee, Jae Young; Shin, Dong Hyuk; Lee, Sangho; Lee, Byung Il
- 발행일
- 2012-05-07
- 유형
- Article
- 저널명
- FEBS Letters
- 권
- 586
- 호
- 9
- 페이지
- 1384 ~ 1388