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Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects
- Jangili, Paramesh;
- Won, Miae;
- Kim, Seo Jin;
- Chun, Jieun;
- Shim, Inseob;
- ... Kim, Jong Seung;
- 외 2명
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17초록
We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5'-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.
키워드
binary drug; SN-38; 5'-DFUR; COX-2; synergistic effect
- 제목
- Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects
- 저자
- Jangili, Paramesh; Won, Miae; Kim, Seo Jin; Chun, Jieun; Shim, Inseob; Kang, Chulhun; Ren, Wen Xiu; Kim, Jong Seung
- 발행일
- 2019-08-19
- 유형
- Article
- 권
- 2
- 호
- 8
- 페이지
- 3532 ~ 3539