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초록
RNA demethylase has recently been known to be associated with cancer development but its selective inhibitors as anti-cancer agents have rarely been investigated to date. Herein, we have developed a fluorescent nanobiosensor which enables efficient quantitative analysis of RNA demethylase ALKBH5 activity and shows a high potential for robust inhibitor screening.
키워드
METTL3-METTL14 COMPLEX; NUCLEAR-RNA; ALKBH5; MOUSE; ASSAY; EXPRESSION; SUBSTRATE; PLATFORM
- 제목
- A fluorescent nanobiosensor for the facile analysis of m(6)A RNA demethylase activity
- 저자
- Yim, Seo-Hee; Cha, Hyung Jin; Park, Se-Jin; Yim, Yeajee; Woo, Jae-Sung; Min, Dal-Hee
- 발행일
- 2020-04-30
- 유형
- Article
- 권
- 56
- 호
- 34
- 페이지
- 4716 ~ 4719