The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex

Yeo, Kwon Joo; Hwang, Eunha; Min, Kyong-Mi; Jee, Jun-Goo; Lee, Chung-Kyung; Hwang, Kwang Yeon; Jeon, Young Ho; Chang, Soo-Ik; Cheong, Hae-Kap

doi:10.1039/c4cc05175k

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The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex

Yeo, Kwon Joo;
Hwang, Eunha;
Min, Kyong-Mi;
Jee, Jun-Goo;
Lee, Chung-Kyung;
... Hwang, Kwang Yeon;
... Jeon, Young Ho;
외 2명

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초록

The heparin complex of rat angiogenin revealed that a heparin strand is fitted into a positively charged groove formed by the dual binding site of rat angiogenin, suggesting that cell adhesion to angiogenin is facilitated by its interaction with substrates on the cell surface and can be inhibited by heparin.

키워드

AMYOTROPHIC-LATERAL-SCLEROSIS; ENDOTHELIAL-CELLS; MONOCLONAL-ANTIBODY; TUMOR-GROWTH; IDENTIFICATION; PROLIFERATION; VARIANTS; OLIGOMER; DISEASE; GLUCOSE

제목: The dual binding site of angiogenin and its inhibition mechanism: the crystal structure of the rat angiogenin-heparin complex

저자: Yeo, Kwon Joo; Hwang, Eunha; Min, Kyong-Mi; Jee, Jun-Goo; Lee, Chung-Kyung; Hwang, Kwang Yeon; Jeon, Young Ho; Chang, Soo-Ik; Cheong, Hae-Kap

DOI: 10.1039/c4cc05175k

발행일: 2014

유형: Article

저널명: Chemical Communications

권: 50

호: 85

페이지: 12966 ~ 12969

언어: ENG

출판사: ROYAL SOC CHEMISTRY

발행국가: 영국

분량: 4 페이지

ISSN: E 1364-548X
P 1359-7345