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Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
- Yang, Jaemoon;
- Lim, Eun-Kyung;
- Lee, Hong Jae;
- Park, Joseph;
- Lee, Sang Cheon;
- ... Lee, Kwangyeol;
- 외 4명
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97초록
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines. (c) 2008 Elsevier Ltd. All rights reserved.
키워드
magnetic nanoparticle; fluorescence; nanohybrid; cancer; cetuximab; SUPERPARAMAGNETIC NANOPARTICLES; QUANTUM DOTS; NANOCRYSTALS; DIAGNOSIS; ANTIBODY
- 제목
- Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection
- 저자
- Yang, Jaemoon; Lim, Eun-Kyung; Lee, Hong Jae; Park, Joseph; Lee, Sang Cheon; Lee, Kwangyeol; Yoon, Ho-Geun; Suh, Jin-Suck; Huh, Yong-Min; Haam, Seungjoo
- 발행일
- 2008-06
- 유형
- Article
- 저널명
- Biomaterials
- 권
- 29
- 호
- 16
- 페이지
- 2548 ~ 2555
- 언어
- ENG
- 출판사
- ELSEVIER SCI LTD
- 발행국가
- 영국
- 분량
- 8 페이지
- ISSN
- E 1878-5905
P 0142-9612