Hypoxia-inducible factor-1 and nuclear factor-kappa B inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

Wu, Cheng-Zhu; Hong, Seong Su; Cai, Xing Fu; Dat, Nguyen Tien; Nan, Ji-Xing; Hwang, Bang Yeon; Lee, Jung Joon; Lee, Dongho

doi:10.1016/j.bmcl.2008.03.028

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Hypoxia-inducible factor-1 and nuclear factor-kappa B inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

Wu, Cheng-Zhu;
Hong, Seong Su;
Cai, Xing Fu;
Dat, Nguyen Tien;
Nan, Ji-Xing;
... Lee, Dongho;
외 2명

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34

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48

초록

Two new meroterpenoids, 12,13-dihydro-12,13-dihydroxybakuchiol (2) and (12'S)-bisbakuchiol C (3), were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). The structures of 2 and 3 were elucidated by spectroscopic and chemical methods. Six meroterpenoids isolated from P. corylifolia and three semi-synthetic analogues were evaluated for HIF-1 and NF-kappa B inhibition, and O-methyl and O-ethylbakuchiols (6 and 7) inhibited HIF-1 and NF-kappa B activation without significantly decreasing the viability of the AGS and HeLa cells, respectively. (c) 2008 Elsevier Ltd. All rights reserved.

키워드

Psoralea corylifolia; Fabaceae; meroterpenoids; hypoxiainducible; factor-1; nuclear factor kappa B; VITRO; CELLS; HIF-1; ACTIVATION; EXPRESSION; KINASE

제목: Hypoxia-inducible factor-1 and nuclear factor-kappa B inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia

저자: Wu, Cheng-Zhu; Hong, Seong Su; Cai, Xing Fu; Dat, Nguyen Tien; Nan, Ji-Xing; Hwang, Bang Yeon; Lee, Jung Joon; Lee, Dongho

DOI: 10.1016/j.bmcl.2008.03.028

발행일: 2008-04-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 18

호: 8

페이지: 2619 ~ 2623