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Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling
- Kwak, Jae-Hwan;
- Cho, Young Ae;
- Jang, Jae-Yong;
- Seo, Seung-Yong;
- Lee, Heesoon;
- ... Lee, Kiho;
- 외 4명
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15초록
Concise and practical synthesis of 4-O-methylhonokiol was achieved in 34% overall yield. The key features of our synthesis include chemoselective ortho-mono bromination of phenol as well as biaryl formation via Suzuki-Miyaura cross-coupling, in which bromophenol was reacted with potassium aryltrifluoroborate using Pd(OAc)(2) and RuPhos under microwave conditions. (C) 2011 Elsevier Ltd. All rights reserved.
키워드
Neolignan; 4-O-Methylhonokiol; Suzuki-Miyaura cross-coupling; Potassium aryltrifluoroborate; CONCISE SYNTHESIS; NEOLIGNANS; ACIDS
- 제목
- Expedient synthesis of 4-O-methylhonokiol via Suzuki-Miyaura cross-coupling
- 저자
- Kwak, Jae-Hwan; Cho, Young Ae; Jang, Jae-Yong; Seo, Seung-Yong; Lee, Heesoon; Hong, Jin Tae; Han, Sang-Bae; Lee, Kiho; Kwak, Young-Shin; Jung, Jae-Kyung
- 발행일
- 2011-12-02
- 유형
- Article
- 저널명
- Tetrahedron
- 권
- 67
- 호
- 48
- 페이지
- 9401 ~ 9404