A novel and efficient amidation of 2-aminothiazole

Choi, Minho; Won, Sun-Woo; Jo, Hyeju; Viji, Mayavan; Seo, Seung-Yong; Lee, Yeon-Ju; Lee, Hyi-Seung; Lee, Heesoon; Hong, Jin Tae; Kwak, Young-Shin; Jung, Jae-Kyung

doi:10.1016/j.tetlet.2014.10.031

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A novel and efficient amidation of 2-aminothiazole

Choi, Minho;
Won, Sun-Woo;
Jo, Hyeju;
Viji, Mayavan;
Seo, Seung-Yong;
외 6명

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4

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4

초록

A facile and efficient method has been developed for the synthesis of novel thiazolyl carboxamide derivatives by direct reaction of the corresponding esters and 2-aminothiazole. Treatment of 2-aminothiozole with various carboxylic esters in the presence of t-butylmagnesium chloride provides the biologically significant thiazolyl carboxamide derivatives in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.

키워드

Amide; 2-Aminothiazole; Carboxamide; Transamidation; t-Butylmagnesium chloride; AMIDE BOND FORMATION; CARBOXYLIC-ACIDS; MANUFACTURE; MELOXICAM; AMINES

제목: A novel and efficient amidation of 2-aminothiazole

저자: Choi, Minho; Won, Sun-Woo; Jo, Hyeju; Viji, Mayavan; Seo, Seung-Yong; Lee, Yeon-Ju; Lee, Hyi-Seung; Lee, Heesoon; Hong, Jin Tae; Kwak, Young-Shin; Jung, Jae-Kyung

DOI: 10.1016/j.tetlet.2014.10.031

발행일: 2014-11-26

유형: Article

저널명: Tetrahedron Letters

권: 55

호: 48

페이지: 6582 ~ 6584