A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure

초록

In this article we review the history of key epidemiologicalstudies of populations exposed to ionizing radiation. We high-light historical and recent findings regarding radiation-associated risks for incidence and mortality of cancer andnon-cancer outcomes with emphasis on study design andmethods of exposure assessment and dose estimation alongwith brief consideration of sources of bias for a few of themore important studies. We examine the findings from theepidemiological studies of the Japanese atomic bomb survivors,persons exposed to radiation for diagnostic or therapeutic pur-poses, those exposed to environmental sources includingChornobyl and other reactor accidents, and occupationallyexposed cohorts. We also summarize results of pooled studies.These summaries are necessarily brief, but we provide refer-ences to more detailed information. We discuss possible futuredirections of study, to include assessment of susceptible popula-tions, and possible new populations, data sources, study designsand methods of analysis. @2024 by Radiation Research Society

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