Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Kwon, Jaeyoung; Basnet, Sunita; Lee, Jin Woo; Seo, Eun-Kyoung; Tsevegsuren, Nanzad; Hwang, Bang Yeon; Lee, Dongho

doi:10.1016/j.bmcl.2015.05.062

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Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Kwon, Jaeyoung;
Basnet, Sunita;
Lee, Jin Woo;
Seo, Eun-Kyoung;
Tsevegsuren, Nanzad;
... Lee, Dongho;
외 1명

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초록

Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells. (C) 2015 Elsevier Ltd. All rights reserved.

키워드

Sophora alopecuroides L.; Flavonostilbenes; Nitric oxide production inhibitor; RESVERATROL OLIGOMERS; BIOMIMETIC SYNTHESIS; FLAVANONES; ROOTS; FLAVONOSTILBENES; FLAVONOIDS; XANTHONES; ALKALOIDS

제목: Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

저자: Kwon, Jaeyoung; Basnet, Sunita; Lee, Jin Woo; Seo, Eun-Kyoung; Tsevegsuren, Nanzad; Hwang, Bang Yeon; Lee, Dongho

DOI: 10.1016/j.bmcl.2015.05.062

발행일: 2015-08-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 25

호: 16

페이지: 3314 ~ 3318

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 5 페이지

ISSN: E 1464-3405
P 0960-894X