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Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata
- Han, X.H.;
- Hwang, J.H.;
- Hong, S.S.;
- Choe, S.;
- Lee, C.;
- ... Lee, D.;
- 외 4명
Citations
SCOPUS
2초록
Two new benzylated flavonoids, 5,7,4′-trihydroxy-6-p- hydroxybenzylflavanone (1) and 5,7,4′-trihydroxy-6,8-di-p- hydroxybenzylflavanone (2) together with six known flavonoids, kaempferol (3), artocarpesin (4), cycloartocarpesin (5), cudraflavone D (6), gericudranin E (7), and leachianone G (8) have been isolated from the root bark of Cudrania tricuspidata. The structures of 1 and 2 were characterized based on spectroscopic data including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects of monoamine oxidase (MAO). Among them, kaempferol (3), artocarpesin (4), and cudraflavone D (6) showed moderate inhibitory effects with IC50 values of 82.3, 30.8, and 71.8 μM, respectively.
키워드
Benzylated flavonoid; Cudrania tricuspidata; Monoamine oxidase inhibitor; Moraceae; 5,7,4' trihydroxy 6 p hydroxybenzylflavanone; 5,7,4' trihydroxy 6,8 di p hydroxybenzylflavanone; amine oxidase (flavin containing); artocarpesin; cudraflavone; Curdrania tricuspidata extract; cycloartocarpesin; flavonoid; gericudranin e; kaempferol; leachianone g; unclassified drug; animal tissue; article; carbon nuclear magnetic resonance; controlled study; Curdrania tricuspidata; drug activity; heteronuclear multiple quantum coherence; IC 50; medicinal plant; mouse; nonhuman; nuclear magnetic resonance; plant root; proton nuclear magnetic resonance; thin layer chromatography
- 제목
- Monoamine oxidase inhibitory flavonoids from the root bark of Cudrania tricuspidata
- 저자
- Han, X.H.; Hwang, J.H.; Hong, S.S.; Choe, S.; Lee, C.; Lee, M.S.; Lee, D.; Lee, M.K.; Lee, M.K.; Hwang, B.Y.
- 발행일
- 2010
- 유형
- Article
- 권
- 16
- 호
- 2
- 페이지
- 75 ~ 79