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Facile Esterification of Alcohols with 2-Acyl-4,5-dichloropyridazin-3(2H)-ones under Friedel-Crafts Conditions
- Kim, Bo Ram;
- Sung, Gi Hyeon;
- Ryu, Ki Eun;
- Yoon, Hyo Jae;
- Lee, Sang-Gyeong;
- 외 1명
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9초록
This paper describes the esterification of aromatic and aliphatic alcohols by using 2-acyl-4,5-dichloropyridazin-3(2H)-ones as an acyl source under Friedel Crafts conditions. Twelve alcohols were reacted with four 2-acyl-4,5-dichloropyridazin-3(2H)-ones in the presence of AlCl3 in tetrahydrofuran at room temperature to give the corresponding esters in moderate to excellent yields. Thus, 2-acylpyridazin-3(2H)-ones serve as good and atom-economic acyl sources for the esterification of aromatic alcohols under Friedel Crafts conditions, representing a rapid, practical, and efficient method of esterification.
키워드
acylation; esterification; Friedel-Crafts condition; sustainable chemistry; synthetic methods; CARBOXYLIC-ACIDS; EFFICIENT SYNTHESIS; ESTERS; ACYLATION; CATALYSTS; AGENT; CARBOXAMIDES; CONDENSATION; CHLORIDE; MILD
- 제목
- Facile Esterification of Alcohols with 2-Acyl-4,5-dichloropyridazin-3(2H)-ones under Friedel-Crafts Conditions
- 저자
- Kim, Bo Ram; Sung, Gi Hyeon; Ryu, Ki Eun; Yoon, Hyo Jae; Lee, Sang-Gyeong; Yoon, Yong-Jin
- 발행일
- 2014-08
- 유형
- Article
- 저널명
- Synlett
- 권
- 25
- 호
- 13
- 페이지
- 1909 ~ 1915