Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Song, No-Joon; Choi, Seri; Rajbhandari, Prashant; Chang, Seo-Hyuk; Kim, Suji; Vergnes, Laurent; Kwon, So-Mi; Yoon, Jung-Hoon; Lee, Sukchan; Ku, Jin-Mo; Lee, Jeong-Soo; Reue, Karen; Koo, Seung-Hoi; Tontonoz, Peter; Park, Kye Won

doi:10.1038/NCHEMBIO.2081

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Prdm4 induction by the small molecule butein promotes white adipose tissue browning

Song, No-Joon;
Choi, Seri;
Rajbhandari, Prashant;
Chang, Seo-Hyuk;
Kim, Suji;
... Koo, Seung-Hoi;
외 9명

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초록

Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4 dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.

키워드

FAT DEVELOPMENT; ADIPOCYTES; OBESITY; THERMOGENESIS; EXPRESSION; ABLATION; MOUSE; CELL

제목: Prdm4 induction by the small molecule butein promotes white adipose tissue browning

저자: Song, No-Joon; Choi, Seri; Rajbhandari, Prashant; Chang, Seo-Hyuk; Kim, Suji; Vergnes, Laurent; Kwon, So-Mi; Yoon, Jung-Hoon; Lee, Sukchan; Ku, Jin-Mo; Lee, Jeong-Soo; Reue, Karen; Koo, Seung-Hoi; Tontonoz, Peter; Park, Kye Won

DOI: 10.1038/NCHEMBIO.2081

발행일: 2016-07

유형: Article

저널명: Nature Chemical Biology

권: 12

호: 7

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