Neural Organoids, a Versatile Model for Neuroscience

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17
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19

초록

Three-dimensional cultures of human neural tissue/organlike structures in vitro can be achieved by mimicking the developmental processes occurring in vivo. Rapid progress in the field of neural organoids has fueled the hope (and hype) for improved understanding of brain development and functions, modeling of neural diseases, discovery of new drugs, and supply of surrogate sources of transplantation. In this short review, we summarize the state-of-the-art applications of this fascinating tool in various research fields and discuss the reality of the technique hoping that the current limitations will soon be overcome by the efforts of ingenious researchers.

키워드

in vitro modelingneurodevelopmentorganoidcentral nervous systemhuman pluripotent stem cellsneurological disordersPLURIPOTENT STEM-CELLSCEREBRAL ORGANOIDSSELF-ORGANIZATIONBRAIN ORGANOIDSHUMAN ESFEATURESPOLARITYREVEALTISSUE
제목
Neural Organoids, a Versatile Model for Neuroscience
저자
Lee, Ju-HyunSun, Woong
DOI
10.14348/molcells.2022.2019
발행일
2022-02
유형
Review
저널명
Molecules and Cells
45
2
페이지
53 ~ 64