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A facile one-pot regioselective synthesis of functionalized novel benzo[f] chromeno[4,3-b][1,7]naphthyridines and benzo[f][1,7]naphthyridines via an imino Diels-Alder reaction
- Arepalli, Sateesh Kumar;
- Park, Byeongwoo;
- Jung, Jae-Kyung;
- Lee, Kiho;
- Lee, Heesoon
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15초록
A novel series of functionalized 13H-benzo[f]chromeno[4,3-b][1,7]naphthyridines and 1,3-diphenylA-benzo[f][1,7]naphthyridines have been synthesized by an efficient regioselective one -pot multicomponent synthesis through intra and intermolecular imino Diels-Alder reaction. In this method, we have achieved complete regioselectivity and atom economy with polysubstituted core motifs in moderate to good yields. The proposed mechanism of this reaction has also discussed. (C) 2016 Elsevier Ltd. All rights reserved.
키워드
13H-Benzo[f]chromeno[4,3-b]; [1,7]naphthyridines; 1,3-Diphenylbenzo[f][1,7]naphthyridines; Imino Diels-Alder reaction; Atom economy; One-pot multicomponent reaction; TOPOISOMERASE-I INHIBITORS; NF-KAPPA-B; ACID N-(SUBSTITUTED)PHENYLAMIDE DERIVATIVES; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; ANTICANCER AGENTS; ORGANIC-SYNTHESIS; CAMPTOTHECIN; YB(OTF)(3); ANALOGS
- 제목
- A facile one-pot regioselective synthesis of functionalized novel benzo[f] chromeno[4,3-b][1,7]naphthyridines and benzo[f][1,7]naphthyridines via an imino Diels-Alder reaction
- 저자
- Arepalli, Sateesh Kumar; Park, Byeongwoo; Jung, Jae-Kyung; Lee, Kiho; Lee, Heesoon
- 발행일
- 2017-02-01
- 유형
- Article
- 권
- 58
- 호
- 5
- 페이지
- 449 ~ 454