A Three-Dimensional and Sensitive Bioassay Based on Nanostructured Quartz Combined with Viral Nanoparticles

Lee, Jong-Hwan; Kim, Jung Suk; Park, Jin-Seung; Lee, Wonbae; Lee, Kyung Eun; Han, Sung-Sik; Lee, Kyu Back; Lee, Jeewon

doi:10.1002/adfm.200902054

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A Three-Dimensional and Sensitive Bioassay Based on Nanostructured Quartz Combined with Viral Nanoparticles

Lee, Jong-Hwan;
Kim, Jung Suk;
Park, Jin-Seung;
Lee, Wonbae;
Lee, Kyung Eun;
... Lee, Kyu Back;
... Lee, Jeewon;
외 1명

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초록

An effective mask-free method for fabricating high-aspect-ratio pillarlike nanostructures over a large area of a quartz surface via a simple O(2) and CF(4) two-step reactive ion etching (RIE) procedure is developed. The nanostructured quartz surfaces are successfully combined with the engineered viral particles derived from hepatitis B virus capsid, yielding a novel 3D assay system with attomolar sensitivity, which has great potential for use in sensitive and early detection of various disease

키워드

bioassay; nanostructure; quartz; viral nanoparticle; ELECTRON CRYOMICROSCOPY; ESCHERICHIA-COLI; SOLID SUPPORTS; QUANTUM DOTS; PROTEIN-A; SURFACES; SILICON; IMMUNOASSAYS; MICROARRAYS; PARTICLES

제목: A Three-Dimensional and Sensitive Bioassay Based on Nanostructured Quartz Combined with Viral Nanoparticles

저자: Lee, Jong-Hwan; Kim, Jung Suk; Park, Jin-Seung; Lee, Wonbae; Lee, Kyung Eun; Han, Sung-Sik; Lee, Kyu Back; Lee, Jeewon

DOI: 10.1002/adfm.200902054

발행일: 2010-06-23

유형: Article

저널명: Advanced Functional Materials

권: 20

호: 12

페이지: 2004 ~ 2009