Continuous flow reactions in water for the synthesis of propargylamines via a metal-free decarboxylative coupling reaction

Jung, Bongkyun; Park, Kyungho; Song, Kwang Ho; Lee, Sunwoo

doi:10.1016/j.tetlet.2015.06.029

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Continuous flow reactions in water for the synthesis of propargylamines via a metal-free decarboxylative coupling reaction

Jung, Bongkyun;
Park, Kyungho;
Song, Kwang Ho;
Lee, Sunwoo

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12

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12

초록

A range of propargylamines was synthesized via the metal-free decarboxylative coupling of alkynyl carboxylic acids with amines and paraformaldehyde in water, using a continuous flow reaction system. Aryl- and alkyl-substituted propiolic acids were found to react with secondary amines in the presence of paraformaldehyde, at 140 degrees C in water to give the desired propargylamines in good yield. (C) 2015 Elsevier Ltd. All rights reserved.

키워드

Flow reaction; Decarboxylative coupling; Propargylamine; Metal-free; Propiolic acid; ONE-POT SYNTHESIS; ALKYNYL CARBOXYLIC-ACIDS; CATALYZED SONOGASHIRA REACTION; C-H ACTIVATION; ORGANIC-SYNTHESIS; GREEN CHEMISTRY; PROPIOLIC ACID; ASYMMETRIC-SYNTHESIS; SELECTIVE SYNTHESIS; SECONDARY-AMINES

제목: Continuous flow reactions in water for the synthesis of propargylamines via a metal-free decarboxylative coupling reaction

저자: Jung, Bongkyun; Park, Kyungho; Song, Kwang Ho; Lee, Sunwoo

DOI: 10.1016/j.tetlet.2015.06.029

발행일: 2015-08-05

유형: Article

저널명: Tetrahedron Letters

권: 56

호: 32

페이지: 4697 ~ 4700

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 4 페이지

ISSN: P 0040-4039