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A pH-Responsive Glycyrrhetinic-Acid-Modified Small-Molecule Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC)
- Singh, Hardev;
- Lim, Ja-Yun;
- Sharma, Amit;
- Yoon, Dae Wui;
- Kim, Ji Hyeon;
- ... Kim, Jong Seung;
- 외 4명
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21초록
We report a glycyrrhetinic-acid (GA)-decorated small-molecule conjugate for pH-triggered near-infrared (NIR) fluorescence imaging of hepatocellular carcinoma (HCC). Our in vitro studies demonstrated that the conjugate, referred to as NIR-GA, was efficiently taken up by liver cancer cell lines such as HepG2 and Huh7 through an endocytic pathway mediated by GA receptors. As suggested by co-localization studies, NIR-GA mainly localized in the lysosome, where the acidic pH results in the activation of the fluorescent dye through H+-triggered spirolactam ring opening to give strong fluorescence in the NIR region.
키워드
fluorescent probes; glycyrrhetinic acid; hepatocellular carcinoma; imaging agents; natural products; INFRARED FLUORESCENT-PROBES; ASIALOGLYCOPROTEIN RECEPTOR; CANCER-THERAPY; LIVING CELLS; NANOPARTICLES; PRODRUG; BINDING; DESIGN
- 제목
- A pH-Responsive Glycyrrhetinic-Acid-Modified Small-Molecule Conjugate for NIR Imaging of Hepatocellular Carcinoma (HCC)
- 저자
- Singh, Hardev; Lim, Ja-Yun; Sharma, Amit; Yoon, Dae Wui; Kim, Ji Hyeon; Yang, Zhigang; Qu, Junle; Kim, Jinkwan; Lee, Seung Gwan; Kim, Jong Seung
- 발행일
- 2019-02-15
- 유형
- Article
- 저널명
- ChemBioChem
- 권
- 20
- 호
- 4
- 페이지
- 614 ~ 620