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Direct Synthesis of Pyrazolo[5,1-alpha]isoindoles via Intramolecular Palladium-Catalyzed C-H Bond Activation
- Choi, Young Lok;
- Lee, Hyuk;
- Kim, Bum Tae;
- Choi, Kihang;
- Heo, Jung-Nyoung
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38초록
An efficient. direct synthesis of pyrazolo-[5.1-alpha]isoindoles employing a palladium-catalyzed intramolecular C-H bond activation of 1-(2-halobenzyl)pyrazoles has been developed The use of lithium chloride (LICI) was found to be essential in these reactions, to suppress further C H bond activation at the C-3 position of pyrazolo[5,1-alpha]isoindole, when C-3 is unsubstituted This protocol can be applied to the synthesis of a pyrazolo(5,1-alpha]isoqumnoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-alpha]isoindole using seciuential intra- and intermolecular C-H bond activation
키워드
C-H activation; direct arylation; palladium; pyrazoles; DIRECT ARYLATION; NITROGEN-HETEROCYCLES; ROOM-TEMPERATURE; BENZOIC-ACIDS; ARYL; FUNCTIONALIZATION; POTENT; 1,2,3-TRIAZOLES; 2H-INDAZOLES; LIGANDS
- 제목
- Direct Synthesis of Pyrazolo[5,1-alpha]isoindoles via Intramolecular Palladium-Catalyzed C-H Bond Activation
- 저자
- Choi, Young Lok; Lee, Hyuk; Kim, Bum Tae; Choi, Kihang; Heo, Jung-Nyoung
- 발행일
- 2010-08
- 유형
- Article
- 권
- 352
- 호
- 11-12
- 페이지
- 2041 ~ 2049