Chromofluorescent indicator for intracellular Zn2+/Hg2+ dynamic exchange

  • Lee, Jeong Won
  • Jung, Hyo Sung
  • Kwon, Pil Seung
  • Kim, Jong Wan
  • Bartsch, Richard A.
  • ... Kim, Jong Seung
  • 외 2명
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초록

The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ-Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg2+. This results in the concomitant export of Hg2+ from the cells, showing that NABO can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.

키워드

FLUORESCENT CHEMOSENSORZINC-DEFICIENCYPETMERCURYCHOLESTEROLEMISSIONTHIOLSGROWTHSENSORCOPPER
제목
Chromofluorescent indicator for intracellular Zn2+/Hg2+ dynamic exchange
저자
Lee, Jeong WonJung, Hyo SungKwon, Pil SeungKim, Jong WanBartsch, Richard A.Kim, YoungmeeKim, Sung-JinKim, Jong Seung
DOI
10.1021/ol801482n
발행일
2008-09-04
유형
Article
저널명
Organic Letters
10
17
페이지
3801 ~ 3804