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Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle
- Pak, P.J.;
- Go, E.B.;
- Hwang, M.H.;
- Lee, D.G.;
- Cho, M.J.;
- ... Chung, N.;
- 외 1명
Citations
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4초록
Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anticancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment. © The Korean Society for Applied Biological Chemistry 2016.
키워드
Citrate synthesis; Drug delivery system; Gold nanoparticle; Quercetin
- 제목
- Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle
- 저자
- Pak, P.J.; Go, E.B.; Hwang, M.H.; Lee, D.G.; Cho, M.J.; Joo, Y.H.; Chung, N.
- 발행일
- 2016
- 유형
- Article
- 권
- 59
- 호
- 2
- 페이지
- 145 ~ 147
- 언어
- ENG
- 출판사
- Korean Society for Applied Biological Chemistry
- 발행국가
- 대한민국
- 분량
- 3 페이지
- ISSN
- E 2234-7941
P 1976-0442