Metalloprobes for gasotransmitters/biothiols linked diseases: innovation-to-implementation

초록

Early detection of diseases associated with gasotransmitters and biothiols is crucial for improving therapeutic outcomes and increasing patient survival rates. Although metal-complex-based optical probes (metalloprobes) show promise for diagnostic uses, the healthcare community has not yet reached a consensus on their clinical utility. From the perspective of a coordination chemist, this review delves into the design and applications of metalloprobes for detecting gasotransmitters and biothiols, presenting a vital step for advancing clinical diagnostics in human healthcare. By highlighting the related prior studies, which have substantially contributed to the field during 2000-2024, the review sheds light on the needs, opportunities, challenges, and latest developments in the field of metalloprobes. It discusses the fundamental principles of metal-luminophore coordination, signal transduction mechanisms, detection thresholds, and real-time applications in complex biological matrices such as human blood plasma, serum, urine, and also offers insights into cellular investigations. Additionally, the review offers a critical discussion and analysis of the advantages and limitations of metalloprobes, with an emphasis on future challenges and opportunities for commercializing task-specific metalloprobes in the point-of-care testing (POCT) market. We envisage that this careful review will inspire further research to reveal the intricate roles of these biomolecules and driving innovations in bioassays, and therapeutic interventions for complex diseases (innovations-to-implementations, I-2-I).

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