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A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells
- Bhuniya, Sankarprasad;
- Lee, Min Hee;
- Jeon, Hyun Mi;
- Han, Ji Hye;
- Lee, Jae Hong;
- ... Kim, Jong Seung;
- 외 3명
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85초록
We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug 6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 is able to monitor drug delivery and cellular imaging.
키워드
APPENDED NAPHTHALIMIDE; TARGETED DELIVERY; DRUG-RELEASE; NANOPARTICLES; PRODRUG; APOPTOSIS; THERAPY
- 제목
- A fluorescence off-on reporter for real time monitoring of gemcitabine delivery to the cancer cells
- 저자
- Bhuniya, Sankarprasad; Lee, Min Hee; Jeon, Hyun Mi; Han, Ji Hye; Lee, Jae Hong; Park, Nayoung; Maiti, Sukhendu; Kang, Chulhun; Kim, Jong Seung
- 발행일
- 2013
- 유형
- Article
- 권
- 49
- 호
- 64
- 페이지
- 7141 ~ 7143