Palladium-Catalyzed Oxidative Aminocarbonylation by Decarboxylative Coupling: Synthesis of Alkynyl Amides

Hwang, Jinil; Choi, Jinseop; Park, Kyungho; Kim, Wonyoung; Song, Kwang Ho; Lee, Sunwoo

doi:10.1002/ejoc.201403644

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Palladium-Catalyzed Oxidative Aminocarbonylation by Decarboxylative Coupling: Synthesis of Alkynyl Amides

Hwang, Jinil;
Choi, Jinseop;
Park, Kyungho;
Kim, Wonyoung;
Song, Kwang Ho;
외 1명

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초록

Alkynyl amides were synthesized from a palladium-catalyzed coupling reaction of alkynyl carboxylic acids and amines under carbon monoxide. The reaction was conducted with palladium(II) acetate (5 mol-%) and silver(I) oxide (1.0 equiv.) in acetonitrile at 80 degrees C for 1 h. This method provides good to moderate product yields and good functional group tolerance towards ketone, ester, and nitrile groups.

키워드

Synthetic methods; Palladium; Carbonylation; Alkynes; Amides; ONE-POT SYNTHESIS; CARBOXYLIC-ACIDS; PROPIOLIC ACID; ARYL HALIDES; CARBON; CARBONYLATION; EFFICIENT; ESTERS; ALPHA; SP(2)

제목: Palladium-Catalyzed Oxidative Aminocarbonylation by Decarboxylative Coupling: Synthesis of Alkynyl Amides

저자: Hwang, Jinil; Choi, Jinseop; Park, Kyungho; Kim, Wonyoung; Song, Kwang Ho; Lee, Sunwoo

DOI: 10.1002/ejoc.201403644

발행일: 2015-04

유형: Article

저널명: European Journal of Organic Chemistry

권: 2015

호: 10

페이지: 2235 ~ 2243