Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Yeon, Gyu-Bum; Son, Daryeon; Kang, Phil Jun; Oh, Seung-Min; Lim, Hun; Kang, Hoon-Chul; You, Seungkwon; Kim, Dae-Sung

doi:10.1016/j.scr.2019.101425

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Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Yeon, Gyu-Bum;
Son, Daryeon;
Kang, Phil Jun;
Oh, Seung-Min;
Lim, Hun;
... You, Seungkwon;
... Kim, Dae-Sung;
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초록

X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

제목: Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

저자: Yeon, Gyu-Bum; Son, Daryeon; Kang, Phil Jun; Oh, Seung-Min; Lim, Hun; Kang, Hoon-Chul; You, Seungkwon; Kim, Dae-Sung

DOI: 10.1016/j.scr.2019.101425

발행일: 2019-04

유형: Article

저널명: Stem Cell Research

권: 36