NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

An, Lijun; Liang, Yue; Yang, Xueyuan; Wang, Huimei; Zhang, Jie; Tuerhong, Muhetaer; Li, Dihua; Wang, Chunyan; Lee, Dongho; Xu, Jing; Shuai, Ling; Jin, Jin; Guo, Yuanqiang

doi:10.1016/j.bioorg.2019.103237

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NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

An, Lijun;
Liang, Yue;
Yang, Xueyuan;
Wang, Huimei;
Zhang, Jie;
... Lee, Dongho;
외 7명

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25

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25

초록

Two new ent-atisane-type diterpenoids (1 and 2), three new lathyrane-type diterpenoids (3-5), and seven known analogues (6-12) were isolated from Euphorbia antiquorum. The structures of these diterpenoids were established by analysis of their NMR, MS, and electronic circular dichroism data. The anti-inflammatory activities were evaluated biologically and compounds 1, 4, 7, 8, and 10 displayed strong NO inhibitory effects with IC50, values less than 40 mu M. The potential anti-inflammatory mechanism was also investigated using molecular docking and Western blotting.

키워드

NO inhibitory effects; Euphorbia antiquorum; Diterpenoids; Inflammation; Molecular docking; STRUCTURALLY DIVERSE DITERPENOIDS; ANTI-NEUROINFLAMMATORY AGENTS; INGOL-TYPE DITERPENES; JATROPHANE DITERPENOIDS; TIGLIANE DITERPENOIDS; BIOLOGICAL EVALUATION; MULTIDRUG-RESISTANCE; ROOTS; LATEX; ESTERS

제목: NO inhibitory diterpenoids as potential anti-inflammatory agents from Euphorbia antiquorum

저자: An, Lijun; Liang, Yue; Yang, Xueyuan; Wang, Huimei; Zhang, Jie; Tuerhong, Muhetaer; Li, Dihua; Wang, Chunyan; Lee, Dongho; Xu, Jing; Shuai, Ling; Jin, Jin; Guo, Yuanqiang

DOI: 10.1016/j.bioorg.2019.103237

발행일: 2019-11

유형: Article

저널명: Bioorganic Chemistry

권: 92