NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Ma, Jun; Ren, Quanhui; Dong, Bangjian; Shi, Zhaoyu; Zhang, Jie; Jin, Da-Qing; Xu, Jing; Ohizumi, Yasushi; Lee, Dongho; Guo, Yuanqiang

doi:10.1016/j.bioorg.2017.12.008

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NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

Ma, Jun;
Ren, Quanhui;
Dong, Bangjian;
Shi, Zhaoyu;
Zhang, Jie;
... Lee, Dongho;
외 4명

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35

초록

Our continuous search for new nitric oxide (NO) inhibitory substances as anti-neuroinflammatory agents for AD resulted in the isolation of one new labdane diterpenoid and three new guaiane sesquiterpenoids, as well as ten known compounds from Blumea balsamifera. Their structures were elucidated by NMR spectroscopic data analysis and the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The anti-neuroinflammatory effects were examined by inhibiting NO release in LPS-induced murine microglial BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed the interactions of bioactive compounds with the iNOS protein. (C) 2017 Elsevier Inc. All rights reserved.

키워드

Blumea balsamifera; Sesquiterpenoids; Diterpenoids; NO inhibitory activities; Molecular docking; ALZHEIMERS-DISEASE; ANTICANCER ACTIVITIES; INOS PROTEIN; TRITERPENOIDS; DITERPENOIDS; FLAVONOIDS; EXTRACTS; CELLS; EPIDEMIOLOGY; METABOLITES

제목: NO inhibitory constituents as potential anti-neuroinflammatory agents for AD from Blumea balsamifera

저자: Ma, Jun; Ren, Quanhui; Dong, Bangjian; Shi, Zhaoyu; Zhang, Jie; Jin, Da-Qing; Xu, Jing; Ohizumi, Yasushi; Lee, Dongho; Guo, Yuanqiang

DOI: 10.1016/j.bioorg.2017.12.008

발행일: 2018-02

유형: Article

저널명: Bioorganic Chemistry

권: 76

페이지: 449 ~ 457

언어: ENG

출판사: ACADEMIC PRESS INC ELSEVIER SCIENCE

발행국가: 미국

분량: 9 페이지

ISSN: E 1090-2120
P 0045-2068