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Site-specific incorporation of μ-N-crotonyllysine into histones
- Kim, C.H.;
- Kang, M.;
- Kim, H.J.;
- Chatterjee, A.;
- Schultz, P.G.
Citations
SCOPUS
116초록
A novel post-translationally modified amino acid, crotonyllysine (Kcr), was genetically incorporated into proteins in bacterial and mammalian cells using an evolved pyrrolysyl-tRNA/synthetase-tRNA pair. The ability to produce histones with homogenous, site-specific Kcr modifications will be valuable in elucidating the biological role of this recently identified post-translational modification. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
키워드
Crotonylations; Histones; Nonnatural amino acids; Post-translational modifications; Crotonylations; Histones; Mammalian cells; Modified amino acids; Non natural amino acids; Post-translational modifications; Site-specific; Amino acids; Proteins; amino acid transfer RNA ligase; drug derivative; epsilon N crotonyllysine; epsilon-N-crotonyllysine; histone; lysine; recombinant protein; article; cell line; chemistry; Escherichia coli; genetics; human; metabolism; mutation; protein engineering; protein processing; Amino Acyl-tRNA Synthetases; Cell Line; Escherichia coli; Histones; Humans; Lysine; Mutation; Protein Engineering; Protein Processing, Post-Translational; Recombinant Proteins
- 제목
- Site-specific incorporation of μ-N-crotonyllysine into histones
- 저자
- Kim, C.H.; Kang, M.; Kim, H.J.; Chatterjee, A.; Schultz, P.G.
- 발행일
- 2012
- 유형
- Article
- 권
- 51
- 호
- 29
- 페이지
- 7246 ~ 7249
- 언어
- ENG
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1521-3773
P 1433-7851