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Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha
- Liu, Wenpei;
- Song, Ziteng;
- Wang, Huimei;
- Yang, Xueyuan;
- Joubert, Elizabeth;
- ... Lee, Dongho;
- 외 7명
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17초록
A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-cler-odane diterpenoids (1-5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 mu M). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.
키워드
Nitric oxide inhibitory effects; Ajuga pantantha; Diterpenoids; Inflammation; Molecular docking; Zebrafish model; ANTI-NEUROINFLAMMATORY AGENTS; NEOCLERODANE DITERPENOIDS; INFLAMMATION; AD; MACROSPERMA; INHIBITORS
- 제목
- Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha
- 저자
- Liu, Wenpei; Song, Ziteng; Wang, Huimei; Yang, Xueyuan; Joubert, Elizabeth; Zhang, Jie; Li, Shen; Tuerhong, Muhetaer; Abudukeremu, Munira; Jin, Jin; Xu, Jing; Lee, Dongho; Guo, Yuanqiang
- 발행일
- 2020-08
- 유형
- Article
- 권
- 101