Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

Lee, Hee Joon; Park, Kyungho; Bae, Goun; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo

doi:10.1016/j.tetlet.2011.07.091

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Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

Lee, Hee Joon;
Park, Kyungho;
Bae, Goun;
Choe, Jaehoon;
Song, Kwang Ho;
외 1명

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초록

Unsymmetric diaryl alkynes were synthesized from the palladium-catalyzed decarboxylative coupling of aryl halides and propiolic acid using a continuous flow reaction system. This flow chemistry system continuously gave the desired products in moderate to good yields, and produced less byproduct than was formed in the batch reaction. (C) 2011 Elsevier Ltd. All rights reserved.

키워드

Flow chemistry; Micromixer; Palladium; Diaryl alkynes; Decarboxylative coupling; ALKYNYL CARBOXYLIC-ACIDS; ONE-POT SYNTHESIS; SONOGASHIRA REACTIONS; TERMINAL ACETYLENES; MICROREACTOR SYSTEM; ORGANIC-SYNTHESIS; PALLADIUM; ARYL; CARBON; OPTIMIZATION

제목: Efficient synthesis of unsymmetric diarylalkynes from decarboxylative coupling in a continuous flow reaction system

저자: Lee, Hee Joon; Park, Kyungho; Bae, Goun; Choe, Jaehoon; Song, Kwang Ho; Lee, Sunwoo

DOI: 10.1016/j.tetlet.2011.07.091

발행일: 2011-09-28

유형: Article

저널명: Tetrahedron Letters

권: 52

호: 39

페이지: 5064 ~ 5067